Under the additive model, 2667G>C was associated with an increased risk of CHD in both women (RR 1.57, 95% confidence interval [CI] 1.01–2.44) and men (RR 1.93, 95% CI 1.30–2.88); however, none of the other SNPs were associated with risk of CHD in both men and women ( Table 4 ). Multivariable adjustment did not change these results. Furthermore, among the controls, individual SNPs were associated with plasma CRP levels, with similar associations and directions for both women and men ( Table 4 ). Under the same model, SNPs 2667G>C and 3872C>T were associated with 22–37% lower CRP levels, whereas 4741G>C was associated with ∼40% higher CRP levels. SNPs 1919A>T and 3014G>A were associated with approximately 20% higher CRP levels, whereas 5237A>G was not associated with CRP levels in either men or women.
