Cardiovascular risk factors were higher or more frequent among the cases compared to the controls in both men and women ( Table 1 ), and for most of the CRP genotype frequencies, there were no statistical differences by case and control status ( Table 2 ). The 2667C allele was significantly more frequent among cases than controls in women (p = 0.05) and men (0.006), and the 5237G allele was more frequent among cases then controls in women only (p = 0.004). The observed allele frequencies for all SNPs, except for 5237A>G among women (p = 0.03) and 4741G>C among men (p = 0.001), were within Hardy-Weinberg equilibrium among the controls. The pairwise LD measures and correlation coefficients between CRP polymorphisms were analyzed among the control women and men ( Table 3 ). The minor alleles for 1919A>T and 3014G>A were in high pairwise LD (r2>0.95), whereas 2667G>C, 3872C>T, 4741G>C, and 5237A>G were not in high LD (r2<0.30).
