After preprocessing, the GM volumes of the ROIs were compared between the AUD and control groups. Analysis of covariance was used to identify brain regions within the masks of salience, executive control, or DMNs that had GMV differences [P < 0.01, false discovery rate (FDR)-corrected] between the groups. To exclude the effects of nuisance variables on the structural alteration, sex, age, depression, onset age of alcohol use, total intracranial volume (TIV), and IQ were added as additional covariates.
