These expression data suggest that the diminished myelination of SCZ hGPC-transplanted shiverer brains reflected aberrant oligodendrocytic differentiation from the engrafted SCZ hGPCs. Similarly, since hGPCs give rise to astrocytes as well as oligodendrocytes, the RNA expression data suggest an analogous impediment to astrocytic differentiation. The functional consequences of the latter are especially profound, given the critical role for astrocytes in synaptic development and function; indeed, the relative suppression of astrocytic differentiation by SCZ hGPCs suggests a glial contribution to the impaired synaptic function noted in schizophrenia. In that regard, further functional analysis of SCZ-associated dysregulated hGPC genes identified channel and receptor activity, as well as synaptic transmission, as the most differentially affected functions besides glial differentiation (Figures 4D–E). These disease-linked channel and synapse-associated genes were largely down-regulated in the SCZ hGPCs, and included a number of potassium channel genes (Figure 4D), including KCND2, KCNJ9, KCNK9 and KCNA3, as well as a number of transcripts associated with synaptic development and function (Figure 4E and Table S2). The latter included NXPH1, NLGN3, and LINGO1, among others (Table S3, and Figures S3 and
