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Chunk #13 — RESULTS — SCZ hGPCs showed cell-autonomous misexpression of differentiation-associated genes

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Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia.
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genes, in particular those associated with early oligodendroglial and astroglial lineage progression, which were uniformly down-regulated in the SCZ hGPCs relative to their normal controls (Figures 4C and 4F). These included a coherent set of the key GPC lineage transcription factors OLIG1, OLIG2, SOX10, and ZNF488, as well as genes encoding stage-regulated proteins involved in myelination such as GPR17, UGT8, OMG, and FA2H (Figure 4G; see Table S2 and Figures S3 and S4 for detailed gene expression data).