There was minor p-value inflation in the AA (λ = 1.02), EA (λ = 1.038), and combined (λ = 1.041) discovery samples (Fig. S1). Several variants showed evidence for association at the genome-wide or suggestive significance level (Table 2, Fig. S2). In AAs, the association with SNP rs2394476 located between LRP1B (443 kb upstream) and KYNU (93 kb upstream) surpassed the genome-wide cutoff (p = 1.19 × 10−8, OR = 2.12) and had the same effect direction in all subsets of the data (Fig. 1). GWS evidence was also obtained with SLC25A16 SNP rs2394476 (p = 3.42 × 10−10, OR = 3.7, Fig. 2). Variants in two other regions were highly significant (p < 1.0 × 10−5) in AAs: rs11500237 located 37 kb from KCNA4 (p = 3.21 × 10−7, OR = 2.56, Fig. 3) and rs116441240 located in GNAO1 (p = 5.51 × 10−6, OR = 2.73, Fig. 4). No SNPs approached the GWS level in EAs. There was strong evidence for association with intronic CPVL variant rs11764430 in both AAs (p = 1.38 × 10−4) and EAs (p
