(p = 5.51 × 10−6, OR = 2.73, Fig. 4). No SNPs approached the GWS level in EAs. There was strong evidence for association with intronic CPVL variant rs11764430 in both AAs (p = 1.38 × 10−4) and EAs (p = 4.64 × 10−4), and this SNP was nearly GWS in the combined AA and EA discovery datasets (p = 3.10 × 10−7, OR = 1.60, Fig. 5).Table 2Results (p < 5.0 × 10−7) for GWAS of stimulant dependence in the discovery dataset or combined discovery and replication datasets according to population ancestry. Only the most significant SNP at each locus is shown.A. African AmericansChr: positionSNP IDLocusMADiscoveryReplicationTotalMAF caseMAF controlORP-valueMAF caseMAF controlORP-valueOR [95% C.I.]P-valueDir.a2:143542131rs6721393LRP1B-KYNUC0.190.162.121.19 × 10−80.160.860.150.611.86 [1.47–2.36]3.13 × 10−7+++-10:70255832rs2394476SLC25A16G0.10.033.703.42 × 10−10NANANANA3.70 [2.26–6.06]3.42 × 10−10+x+x11:30076200rs11500237KCNA4C0.120.062.563.21 × 10−70.080.051.540.242.31 [1.64–3.14]2.99 × 10−7++++16:56377908rs116441240GNAO1T0.110.042.735.51 × 10−60.100.042.530.00652.66 [1.64–3.91]1.09 × 10−7++++B. Combined populationsChr: positionSNP IDLocusMADiscoveryAA replicationEA replicationTotalORP-valueMAF caseMAF controlORP-valueMAF caseMAF controlORP-valueORP-valueDir.a7:29061724rs11764430CPVLT1.493.10 × 10−70.260.211.600.00240.140.131.100.341.35 [1.22–1.54]3.05 × 10−7++++++++In (A), the first three symbols are for batches of the discovery dataset analyzed separately, and the fourth symbol is for the replication dataset. In (B), the first three symbols are for batches of the AA discovery dataset analyzed separately, the next three symbols are for batches of the EA discovery dataset analyzed
