Chunk #73 — Determinants of BAC — Genetic polymorphisms in alcohol metabolizing enzymes — Other genes involved in alcohol metabolism: CYP2E1 and rare variants
Recent research has shed light on the role of rare genetic variants in alcohol metabolism (184). Through large-scale sequencing studies, Leger et al., identified a gene network associated with alcohol consumption, including both common variants, such as those in the ADH and ALDH family, and rare variants in genes, such as CYP, UDP-Glycosyltransferase (UGT), and two sulfotransferases (SULT). These later two genes are involved in non-oxidative ethanol metabolism and also contribute to variations in alcohol consumption behaviors. This study highlights the importance of rare genetic variants in understanding the genetic architecture of alcohol metabolism, expanding the scope of research in potential pharmacological targets beyond common variants in ADH and ALDH.
