NTX also modulates amphetamine-induced effects and has a potential in the treatment of amphetamine dependence (Jayaram-Lindstrom et al. 2008a;b). No pharmacogenetics studies were reported for the effects of specific variants on NTX response in amphetamine-dependent subjects. No association was found between the OPRM1 SNP 118A>G, the OPRD1 SNPs rs2234918 (921T>C) and the intronic rs678849, and the OPRK1 SNP rs963549 and outcome of nalmefene treatment for alcoholism (Arias et al. 2008).
