This study highlights the relevant impact that miRNAs could be having in the development of alcohol-related changes in human brain. In general, our results suggest that up-regulation of miRNAs in the frontal cortex of human alcoholics may contribute to the deterioration and concomitant adaptation of neuronal functioning observed in cases of alcohol abuse. The overlap between putative targets of miRNAs and the differentially expressed genes from our previous study provides information on the biological functions and networks of genes regulated by specific miRNAs in human alcoholism. In the future, biochemical validation should be used to determine the extent to which gene regulation by miRNAs could be impacting specific protein levels.
