Alcohol is the most commonly misused substance, both as a standalone drug and in the context of polysubstance use.5 More than 25% of patients with OUD exhibit problematic alcohol use, and, therefore, mitigation of risk for incident or recurrent alcohol use disorder (AUD) presents a salient problem in the treatment of OUD.5,7,8,9 As central nervous system depressants,10 alcohol and opioids can be lethal in combination, leading to increased overdoses and mortality among patients with OUD,11,12 in addition to increased health care utilization.13,14,15 Because problematic alcohol and opioid use are traditionally studied as independent conditions, limited evidence-based strategies exist for mitigation of alcohol-related risk among patients with OUD.
