In order to probe for whether the magnitude of changes in mood and urge to drink differed as a function of genotype differences at Begin Drink Report we added a baseline × genotype parameter to the models shown in Table 3. Results revealed a significant baseline × genotype interaction for Negative Mood (GEE parameter estimate = 0.34, SE = 0.10, z score = 3.33, p = < .01), such that the relationship between Begin Drink Report and End Drink Report for Negative Mood was stronger for carriers of the Asp40 allele than for Asn40 homozygotes. However, controlling for baseline × genotype interactions did not change any of the results reported in Table 3. Lastly, given that eBAC was significantly associated with gender, we controlled for the eBAC × Gender interaction in all of the models above. Results indicated that the eBAC × Gender term was not significant in any of the models above and that the addition of this parameter did not change any of the results reported in Table 3.
