After drinking, carriers of the Asp40 allele reported higher Vigor scores than homozygotes for the Asn40 allele after controlling for gender, eBAC, and Vigor reported at the Begin Drink Report (i.e., at baseline). OPRM1 genotype also had a significant main effect on Negative Mood, after controlling for the covariates described above. Carriers of the Asp40 allele reported significantly lower levels of Negative Mood after drinking, as compared to homozygotes for the Asn40 variant. There were significant BAC × OPRM1 genotype interactions on the mood variables suggesting that although Asp40 carriers reported higher overall Vigor and lower Negative Mood after drinking, as eBAC increased, carriers of the Asp40 allele reported greater decreases in Vigor (Figure 1) and greater increases Negative Mood (Figure 2), compared to individuals who were homozygous for the Asn40 allele (see Table 3).
