Chunk #42 — Materials and Methods — Creating a database of SNPs associated with disease

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High trans-ethnic replicability of GWAS results implies common causal variants.

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yes

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with several genome-wide significant SNPs (SNPs less than 200 Kb from each other), we included in the study the SNP with lowest p-value. Finally, disease-associated SNPs from the MHC region and HLA alleles were not included in the study. In several analyses, we used the log(OR) to ensure symmetry, which does not happen if using OR (i.e. an OR of 2 is equivalent to an OR of 0.5).