For replication attempts to be included in our database, several conservative conditions had to be met. We only recorded attempts in which exactly the same SNP than in the discovery GWAS had been genotyped. Moreover, and to avoid any bias towards associations that replicate across ancestries, we did not gather any replication attempt from the same “discovery” GWAS in which a new disease-associated SNP is described. Third, in all these cases, the p-value considered for the replication report was the one from the GWAS stage. Finally, the OR for each disease-associated SNP was referenced for the allele that had been the risk allele in the discovery study. Thus, OR<1 (and log(OR)<0) means that the minor allele was found as protective in the discovery study, while OR>1 (and log(OR)>0) means that the minor allele appeared as the risk allele. For SNPs with different minor alleles across populations, OR were referenced to the minor allele specific for each population. Instances of the latter are indicated in column “Shift” in Table S5 and the shifted OR is represented in all Figures except when otherwise indicated.
