changes in behavior on cognitive and socialization tests. To that end, we compared SCZ and control chimeras on a battery of behavioral tests that included: 1) the elevated plus maze, a measure of anxiety (Walf and Frye, 2007); 2) the 3-chamber social challenge (Yang et al., 2011); 3) novel object recognition, a focused measure of executive memory (Bevins and Besheer, 2006), and 4) the preference for sucrose water, a test for anhedonia (Barnes et al., 2014; Willner et al., 1987). In each, mice chimerized with one of 3 SCZ or 3 control patient-derived lines were compared; each line was derived from a different patient. Between 6–12 recipient mice were engrafted and tested per cell line, or 17–36 mice per group for each behavioral comparison, with a typically equal balance of male and female recipients. These animals were tested beginning between 30–36 weeks of age, and testing typically lasted 3 weeks. Over the tested age range, the SCZ GPC chimeric mice exhibited a number of significant differences in behavior relative to their control hGPC-engrafted counterparts. Normal control-engrafted mice are significantly more likely to explore the open arms (horizontal segments), whereas SCZ mice spent most of their time in the closed maze
