exhibited a number of significant differences in behavior relative to their control hGPC-engrafted counterparts. Normal control-engrafted mice are significantly more likely to explore the open arms (horizontal segments), whereas SCZ mice spent most of their time in the closed maze arms (vertical segments), consistent with greater anxiety (p=0.036, 2-tailed t test). The SCZ hGPC mice exhibited greater avoidance of the open arms in the elevated plus maze than did their normal hGPC-engrafted controls (n=36 mice/group, each including 12 mice engrafted with hGPCs from each of 3 patients; p=0.036, 2-tailed t test), suggesting that the SCZ hGPC mice were prone to higher anxiety when challenged (Figure 6B). In addition, the SCZ hGPC mice showed less preference for sucrose water), consistent with relative anhedonia (Figure 6C), less interest in stranger mice in the 3-chamber social test (Figure 6D), and relatively poor novel object recognition (Figure 6E), reflecting relative impairment in executive memory.
