Chunk #13 — Materials and Methods

Source

Identification of single nucleotide polymorphisms regulating peripheral blood mRNA expression with genome-wide significance: an eQTL study in the Japanese population.

Embedded

yes

Text

Sequence polymorphisms in the mRNA region targeted by the microarray expression probes may cause hybridization differences due to SNP-in-probe effects. Therefore, SNP-probe pairs were excluded from the analysis if the 60-mer probe was mapped to a genomic location that contained a known SNP showing linkage disequilibrium (LD; r2>0.1) with the SNP of the SNP-probe pair.