Overexpression of miR-212 in striatum reverses the motivational properties of cocaine in rats with extended but not restricted access to cocaine. (A) Striatal miR-212 overexpression reverses the long-term trajectory of cocaine-taking behavior in rats with extended access. (B) Disruption of miR-212 signaling in striatum, achieved by local infusion of a locked nucleic acid (LNA) modified antisense oligonucleotide against miR-212 (LNA-antimiR-212) increases cocaine intake in extended access. Reproduced with permission from (Hollander et al., 2010).
