Knockdown of MeCP2 in striatum reverses the motivational properties of cocaine in rats with extended but not restricted access to cocaine. (A) Lentivirus-mediated knockdown of MeCP2 in the striatum reverses the escalating cocaine intake typically seen in rats with extended access to cocaine. (B) In contract, MeCP2 knockdown does not alter cocaine intake in rats with restricted daily access to the drug. Reproduced with permission from (Im et al., 2010).
