Rodents are the most commonly employed models for FASD research. Rodent models are ideal for exploring basic science questions that relate to molecular biology, synaptic plasticity, and cognition. There is also a vast body of literature on rodent physiology, behavior, anatomy, development, reproduction, and teratology (25, 57). The advantages and disadvantages of each of the models as well as the main routes of exposure used are discussed in detail below.