Mice are the most commonly used mammals in scientific research due to the ease of care, the availability of transgenic and disease models, their short life span and their similarities to human beings in terms of genetics and basic physiology. Mouse models of FASD first began to appear in the early 1980s and seminal work by Dr. Kathleen Sulik paved the way for small mammalian models of FASD (47). The route of administration varies from study to study, with the most common models using i.p. injection (47, 113, 156, 157), s.c. injection (111, 158, 159), voluntary drinking paradigms (91, 160, 161), liquid diets (162–164), or oral intubation (165). Most studies employ chronic exposure paradigms (i.e., throughout pregnancy or throughout the third trimester equivalent), but intermittent exposure is also common, particularly in studies where the i.p. route of ethanol administration is used, and where critical periods of vulnerability are being examined (47, 113, 158, 159, 162, 166, 167). The BACs achieved in most studies range between 80–180 mg/dl (for voluntary drinking or liquid diet) and over 200 mg/dl for studies where
