Of the four regions showing association at P<5×10-7 in the expanded reference group analysis (Supplementary Table 9), it is of interest that the closest gene to the signal at rs1526805 (P=2.2×10-7) is KCNC2 which encodes the Shaw-related voltage-gated potassium channel. Ion channelopathies are well-recognized as causes of episodic central nervous system disease, including seizures, ataxias and paralyses34. It is possible that this may extend to episodic disturbances of mood and behaviour.
