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Chunk #33 — Disease association results — Bipolar disorder (BD)

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
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Amongst the other higher ranked signals in the BD data set (Supplementary Table 7), there is support for the previously suggested importance of GABA neurotransmission (rs7680321 (P=6.2×10-5) in GABRBI encoding a ligand-gated ion channel (GABA A receptor, beta 1))35, glutamate neurotransmission (rs1485171 (P=9.7×10-5) in GRM7 (glutamate receptor, metabotropic 7))35 and synaptic function (rs11089599 (P=7.2 × 10-5) in SYN3 (synapsin III)36).