Chunk #12 — METHODS AND MATERIALS — Data Analysis — Individual and Group Functional Connectivity Analysis

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Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthood.

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Significant group differences in functional coupling with seed ROIs, masked with the a priori mask described above, were determined using a voxel-wise threshold of p<0.005, cluster threshold of 71 voxels, from an additional Monte Carlo estimation as previously described. For identified clusters, connectivity data were extracted from individual PPI maps for correlation with behavioral measures.