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Chunk #11 — METHODS AND MATERIALS — Data Analysis — Individual and Group Functional Connectivity Analysis

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Resiliency in adolescents at high risk for substance abuse: flexible adaptation via subthalamic nucleus and linkage to drinking and drug use in early adulthood.
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time-series (Gitelman et al., 2003). The PPI interaction term was the product of the neuronal time-series and a contrast vector coding for main effect of task (1 for 2-back; −1 for 0-back). This term was convolved with the HRF; PPI model regressors consisted of the interaction term, contrast vector and extracted time-series plus motion regressors from the original design (Friston et al., 1997). Single subject contrasts for the first regressor (interaction term) were calculated and used for second-level two sample t-tests evaluating Low and High resiliency groups.