Some of the P2Y receptors have prominent roles in neurodegenerative diseases. For example, during neuronal injuries, P2Y2, P2Y4, and P2Y6 receptors regulate the phagocytic activity of microglia upon leaked UTP and UDP from injured hippocampal cells.233 Microglia execute the uptake of cellular debris specifically through P2Y6 receptor.233 P2Y1, P2Y4, and P2Y12 are prominent P2YRs in the brain and represent favorable targets for treating neuroinflammatory diseases and neurodegenerative disorders including AD.46,226
