Many updates were also due to large-scale curation projects aimed at improving specific sets of drugs or data. In terms of drugs, many updates were added as part of a project conducted during 2019–2020 aimed at extensive curation of the top 300 drugs in global clinical use, as ascertained from the WHO list of globally prescribed medications (https://www.who.int/publications/i/item/WHOMVPEMPIAU2019.06). Other gap fill-in efforts included improvements to drug–food interactions, chemical structures and drug vocabularies (synonyms, names and codes) as well as increased drug coverage for clinical trials.