Chunk #20 — RESULTS — Smokers at higher genetic risk were more likely to develop nicotine dependence

Source

Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study.

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Through age 38 years, 27% of ever-smokers developed nicotine dependence. Individuals at higher genetic risk were more likely to become nicotine dependent compared to individuals at lower genetic risk and were nicotine dependent at more assessments (HR for nicotine dependence =1.27 [1.09-1.47]; IRR for assessments with nicotine dependence=1.22 [1.06-1.41]) (Figure 4 Panel B).