We now have genome-wide genotyping association study (GWAS) data from the wave 4 twins genotyped on the Illumina 670k custom chip at the Wellcome Trust Sanger Institute. In addition 200+ metabolites, primarily of lipids and their fractions have been determined from all twins, who provided blood samples (n=780) (Kettunen et al, 2012) and cotinine, 3-hydroxycotinine and the nicotine metabolite ratio have been determined for smokers and their cotwins by professor Rachel Tyndale’s lab, University of Toronto for all occasional and daily smokers. We are currently completing the first epigenetic analyses using targeted gene-specific methylation assays, as well as genome-wide approaches (such as the Infinium 450k array).
