The Finnish Twin Cohort Study: an update.
paper
Cited
Public
- Authors
- Kaprio, Jaakko
- Year
- 2013
- Journal
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- PMID
- 23298696
- DOI
- 10.1017/thg.2012.142
- PMCID
- PMC4493754
In 2002 and 2006, review papers have described the Finnish Twin Cohort and studies conducted on these population-based, longitudinal data sets with extensive follow-up data. Three cohorts have been established: the older twin cohort in the 1970s, and the Finntwin12 and Finntwin16 studies initiated in the 1990s. The present review provides on update on the latest data collections conducted since the previous review. These cover the fourth waves of data collection in the older cohort (twins born before 1958) and Finntwin12 (twins born 1983-1987). The fifth wave of data collection in Finntwin16 (twins born 1975-1979) also included assessments of their spouses/partners. An analysis of mortality in the older cohort from 1975 to 2009 indicates that the mortality of adult twins (as individuals) does not differ from the population at large. Based on the cohorts, many sub-studies with more detailed phenotyping and collection of omics data have been conducted or are in progress. We also contribute to numerous national and international collaborations.
Standardized mortality ratios (SMR) of observed to expected mortality among twin individuals in the older twin cohort (with 95% confidence intervals) by sex and five-year age group (the red line). Expected numbers are based on calendar specific mortality rates for the Finnish population in the same sex-age groups. The horizontal line represents an SMR of 1 (or 100%), i.e. the population rates.
Two schematic charts of data collection in the Finntwin12 study (Epidemiological sample and intensive study sample). In the Epidemiological sample five birth cohorts of twins born 1983β1987 were assessed at four waves of data collection. An intensively studied subset were subject to additional data collections in waves 1,2 and 4.
1β20 of 20
| Name | Type |
|---|---|
| 1880β1957 birth cohorts local | cohort |
| 3-hydroxycotinine | drug |
| ability to recognize emotional facial expressions local | phenotype |
| Ability to recognize emotional facial expressions local | phenotype |
| abstainers | phenotype |
| aggressiveness | phenotype |
| alcohol | phenotype |
| alcohol abuse | phenotype |
| alcohol dependence | phenotype |
| alcohol dependence concordant pairs local | cohort |
| alcohol dependence discordant pairs local | cohort |
| Alcohol Problems | phenotype |
| alcohol-related problems | phenotype |
| Alcohol Use | phenotype |
| antisocial personality disorder | phenotype |
| anxiety | phenotype |
| attentiveness local | phenotype |
| Attentiveness local | phenotype |
| back disorders local | phenotype |
| Back disorders local | phenotype |
| Birth cohort 1940s local | cohort |
| Birth cohort 1950s local | cohort |
| blood | drug |
| blood pressure | phenotype |
| body composition | phenotype |
| body weight | phenotype |
| bruxism local | phenotype |
| Cancer incidence local | phenotype |
| cannabis use | phenotype |
| Chemosensory preferences local | phenotype |
| children | cohort |
| chronic bronchitis | phenotype |
| Close Social Relationships local | phenotype |
| coffee | drug |
| cognition | phenotype |
| cotinine | drug |
| Cotwins local | phenotype |
| daily smoking | phenotype |
| dependence | phenotype |
| depression | phenotype |
| diabetes | phenotype |
| diet | drug |
| Dieting local | phenotype |
| Disability pension local | phenotype |
| disc degeneration local | phenotype |
| Disc degeneration local | phenotype |
| DNA collection local | drug |
| Dyads local | cohort |
| dyspnea local | phenotype |
| eating disorders | phenotype |
| EPITRAIN local | cohort |
| executive functioning | phenotype |
| Experienced health local | phenotype |
| externalizing behavior | phenotype |
| extraversion | phenotype |
| Finnish Birth Cohort 1983-1987 local | cohort |
| Finnish national population register local | cohort |
| Finnish speaking subjects local | cohort |
| Finnish Twin Cohort local | cohort |
| Finnish Twin Study of Ageing local | cohort |
| Finnish Twin Study of Ageing (FITSA) local | cohort |
| Finntwin12 | cohort |
| Finntwin16 cohort local | cohort |
| first four waves of data collection local | cohort |
| Food habits local | phenotype |
| general cognitive capacity local | phenotype |
| General cognitive capacity local | phenotype |
| general population | cohort |
| health | phenotype |
| Health related behaviors local | phenotype |
| health status | phenotype |
| Health worker effect local | phenotype |
| Healthy pair effect local | phenotype |
| heavy drinking | phenotype |
| hormone replacement therapy | drug |
| Illnesses local | phenotype |
| impulsivity | phenotype |
| inattention | phenotype |
| intensive cohort local | cohort |
| Intensive Twin Subset local | cohort |
| internalizing disorders | phenotype |
| lipids | drug |
| memory | phenotype |
| men | cohort |
| metabolism | phenotype |
| metabolites | drug |
| mood disorders | phenotype |
| mortality | phenotype |
| motor dexterity local | phenotype |
| Motor dexterity local | phenotype |
| musculoskeletal pain local | phenotype |
| neuroticism | phenotype |
| nicotine | drug |
| Nicotine Addiction Genetics subsample local | cohort |
| nicotine dependence | phenotype |
| nicotine metabolite ratio | phenotype |
| Nordic twin cohorts local | cohort |
| NorTwinCan local | cohort |
| occasional smokers | phenotype |
| Older birth cohorts local | cohort |
| older cohort | cohort |
| other drugs | drug |
| Partners | cohort |
| perceptual speed | phenotype |
| personality traits | phenotype |
| physical activity | phenotype |
| physical activity discordant pairs local | cohort |
| Physical exercise local | phenotype |
| prosocial behavior | phenotype |
| psychiatric disorders | phenotype |
| Reading speed local | phenotype |
| Reduced work capacity local | phenotype |
| Regulation of emotions local | phenotype |
| reward | phenotype |
| saliva | drug |
| same-sexed twin cohort local | cohort |
| Schizotypy | phenotype |
| second-hand smoke | drug |
| second-hand smoke exposure local | phenotype |
| Sedentariness local | phenotype |
| Sense of coherence local | phenotype |
| smoking | phenotype |
| social cognition | phenotype |
| social support | phenotype |
| spatial ability | phenotype |
| stressful life events | phenotype |
| substance use | phenotype |
| suicide | phenotype |
| Swedish speaking subjects local | cohort |
| tea | drug |
| tobacco use | phenotype |
| total cholesterol | phenotype |
| traumatic experiences | phenotype |
| Twin cohort | cohort |
| TwinSpine study local | cohort |
| unknown zygosity group local | cohort |
| unknown zygosity twins local | cohort |
| waist circumference | phenotype |
| Wave 4 twin cohort local | cohort |
| Wave 4 Twins local | cohort |
| Weight changes local | phenotype |
| weight-discordant MZ pairs local | cohort |
| women | cohort |
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