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Chunk #8 — INTRODUCTION

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Alcohol use disorder is associated with increases in frontocentral phase-amplitude coupling strength during resting state.
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In the current project, we seek to identify the phase-amplitude frequency pair domains in which significant differences in AUD-associated PAC appear, and characterize the magnitude and direction of change in AUD-associated PAC. EEG resting state data drawn from COGA participants is used to compare resting state PAC estimates between those with severe AUD (DSM-5, 6+ symptoms) and unaffected controls We focused on the frontocentral EEG channel FZ to illuminate any possible associations between AUD and PAC in the mPFC.