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Chunk #7 — INTRODUCTION

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Alcohol use disorder is associated with increases in frontocentral phase-amplitude coupling strength during resting state.
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While compromised functional connectivity in the brain has been seen with fMRI and EEG coherence in AUD, to date, there have not been any investigations into possible associations between AUD diagnosis and PAC, though acute alcohol intoxication in healthy subjects has revealed reductions in theta-gamma and delta-gamma PAC in frontal and parietal EEG channels during resting state (Lee & Yun, 2014). Identifying new measures to characterize brain networks and functions underlying AUD will deepen our understanding of risk factors and resilience and enable designing effective treatments for AUD.