Chunk #13 — Results — Functional annotation and fine-mapping of risk loci

Source

Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

Embedded

yes

Text

To narrow the credible window of risk loci and identify potentially causal SNPs, we fine-mapped loci using PolyFun+SUSIE30, which identified a credible set for 67 loci. Credible set window lengths were on average 62% of the original set lengths (Supplementary Table 11) and contained a median of 23 credible SNPs (range 1–252). Only one contained a SNP with posterior inclusion probability > 0.95, a missense SNP in the exon of ANAPC4 (rs34811474, R[CGA]>Q[CAA]; Supplementary Table 12).