Chunk #12 — Results — Functional annotation and fine-mapping of risk loci

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Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder.

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Functional annotations were used to gain insights into the functional role of SNPs within the 81 risk loci (Supplementary Table 10): 72 loci contained at least one SNP with Combined Annotation Dependent Depletion (CADD)28 scores suggestive of deleteriousness to gene function (≥12.37), 43 loci contained GWS SNPs with Regulome DB29 scores likely to affect binding, and 23 loci contained at least one SNP in the exon region of a gene.