A multiplex analysis of plasma collected from 24 healthy male subjects after moderate alcohol consumption (50mL of vodka with 200mL orange juice twice daily or only orange juice daily for 4 weeks during dinner) also showed a significant reduction in acute phase proteins, ferritin and α1-antitrypsin as well as pro-inflammatory cytokines IL-1 receptor antagonist and IL-18 (Joosten, van Erk et al. 2012). In contrast, level of anti-inflammatory protein adiponectin increased (Joosten, van Erk et al. 2012). Similarly, plasma adiponectin concentration was increased after 28 days of daily consumption of 450mL of red wine compared with dealcoholized red wine amongst 34 men, in the absence of changes in subcutaneous and abdominal fat contents as well as body weight (Beulens, van Beers et al. 2006).
