We had designed this study to be complementary to equivalent analyses of overall adiposity (as measured by BMI) conducted on many of the same samples [10], [12]–[14],[16],[17]. By focusing on widely-available anthropometric proxies of central adiposity, and targeting replication to those signals which, in the GWAS data, had the most compelling evidence for disproportionate effects on central adiposity, our aim had been to enrich for variants influencing regional rather than overall obesity, and thereby overcome the very strong correlations between these measures.
