We were interested therefore in establishing the extent to which the confirmed, genome-wide associations identified at/near TFAP2B, MSRA and LYPLAL1 were indeed specific for central fat accumulation as opposed to being driven by other highly-correlated anthropometric traits (most notably overall adiposity as measured by BMI). To evaluate this, we used data from the stage 2 replication samples, from which we can expect to obtain less biased estimates of the relative effects across anthropometric phenotypes.
