In the case of TFAP2B, these stage 2 data indicated that, notwithstanding the evidence for discordant effects in the stage 1 data (which led to its selection for follow up), rs987237 showed strong associations with overall adiposity (P = 7.0×10−12 for BMI in stage 2 alone). The association with WC remained only nominally significant in stage 2 (P = 0.02) after adjustment for BMI. The TFAP2B rs987237 G allele was weakly associated with overall fat mass (0.15% difference per-allele [P = 0.02] in 29,316 individuals with bioimpedance data; 0.25% difference per-allele [P = 0.02] in 13,039 additional individuals with dual energy X-ray absorptiometry (DXA) measures: Table S7). In the 7,346 individuals for which we had DXA information on fat distribution, there was no apparent association with percent central fat mass (P = 0.98), although this analysis is underpowered.
