We present the results of a GWA scan for five broad personality factors in a founder population from Sardinia, Italy. Although none of the initial results reaches genome-wide significance using the conservative Bonferroni threshold, several interesting candidate genes map near SNPs exhibiting strong evidence of association - prompting us to examine SNPs with the strongest signals in additional samples. Even when none of the SNPs examined reach genome wide significance in the original scan, we expect that sets of SNPs showing nominally strong associations will be enriched for truly associated SNPs (54, 55).
