SNPs with P-values lower or equal to 10−5 are presented in supplementary Table A (45 SNPs associated with Neuroticism, 54 with Extraversion, 59 with Openness, 112 with Agreeableness, and 33 with Conscientiousness). Table 1 presents the top six SNPs that we sought to replicate in two independent samples. For each trait, we selected six top non-redundant SNPs and excluded those that were both outside of any gene and not in LD with any other surrounding SNPs. Table 1 provides P-values and a standardized measure of effect size (Z), with the sign (+ or −) indicating the direction of the effect.