in HapMap (http://www.hapmap.org) genotype samples of white individuals (0.50). Each A allele of rs1861868 was associated with a 0.75 increase in BMI (P<.001), corresponding to a mean (SD) increase in weight of 2.0 (0.7) kg per allele (Table 1). Individuals with the A allele for rs1861868 were at increased risk of being obese (odds ratio [OR],1.26; P =.006) and of being overweight (OR,1.15; P =.05). The A allele of rs1861868 was also associated with greater waist circumference (P =.003) and weight (P =.002). In a smaller subset of 355 subjects, the same directional associations were seen with total fat mass (P<.001) and with percentage of fat mass (P=.001). Sex-, age-, and age2-adjusted physical activity levels did not differ significantly according to genotype (P =.11).
