Chunk #48 — Results — Deconvolution of bulk RNA-seq of non-demented and AD brains shows a characteristic signature for neurodegeneration

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Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

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structure (AD vs neuropath-free controls) from the brains in the Mayo Clinic and Mount Sinai Brain BankBrain regionsSample sizeNeuronAstrocyteOligodendrocyteMicroglia n Effectp valueEffectp valueEffectp valueEffectp valueMayoAD vs ControlCB119− 0.032.74 × 10−010.058.65 × 10−02− 0.021.07 × 10−01−3.19 × 10−049.19 × 10−01TC119− 0.171.58 × 10−070.235.01 × 10−09− 0.071.8 × 10−02− 2.03 × 10−035.48 × 10−01Mount Sinai Brain BankAD vs ControlAPC184− 0.048.14 × 10−040.068.11 × 10−05− 0.013.36 × 10−02− 3.18 × 10−031.12 × 10−02STG167− 0.083.49 × 10−070.11.45 × 10−07− 0.015.8 × 10−02− 3.17 × 10−035.78 × 10−02PHG160− 0.111.35 × 10−080.135.48 × 10−10− 0.021.79 × 10−03− 3.18 × 10−031.35 × 10−01IFG159− 0.043.12 × 10−030.063.58 × 10−04− 0.014.39 × 10−02−3.98 × 10−031.64 × 10−02Clinical Dementia RatingAPC184− 0.029.38 × 10−040.022.07 × 10−04− 3.43 × 10−031.25 × 10−01− 1.46 × 10−034.95 × 10−03STG167− 0.031.87 × 10−060.043.33 × 10−07− 0.012.1 × 10−02−1.02 × 10−031.49 × 10−01PHG160− 0.048.56 × 10−060.042.85 × 10−06− 0.018.7 × 10−02− 1.94 × 10−032.53 × 10−02IFG159− 0.028.29 × 10−050.031.4 × 10−05− 4.64 × 10−036.7 × 10−02− 1.46 × 10−033.11 × 10−02Braak stagingAPC173− 0.011.21 × 10−020.011.27 × 10−03− 3.09 × 10−032.77 × 10−02− 7.04 × 10−043.12 × 10−02STG158− 0.022.22 × 10−070.022.77 × 10−07− 2.91 × 10−031.17 × 10−01− 5.47 × 10−041.97 × 10−01PHG147− 0.021.83 × 10−060.039.6 ×