Chunk #49 — Results — Deconvolution of bulk RNA-seq of non-demented and AD brains shows a characteristic signature for neurodegeneration

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Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

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1.46 × 10−033.11 × 10−02Braak stagingAPC173− 0.011.21 × 10−020.011.27 × 10−03− 3.09 × 10−032.77 × 10−02− 7.04 × 10−043.12 × 10−02STG158− 0.022.22 × 10−070.022.77 × 10−07− 2.91 × 10−031.17 × 10−01− 5.47 × 10−041.97 × 10−01PHG147− 0.021.83 × 10−060.039.6 × 10−08− 0.011.49 × 10−03− 3.71 × 10−044.97 × 10−01IFG152− 0.011.01 × 10−020.018.56 × 10−04− 3.55 × 10−032.37 × 10−02− 1.01 × 10−031.74 × 10−02Mean amyloid plaquesAPC184−1.88 × 10−033.6 × 10−032.82 × 10−031.03 × 10−04− 7.99 × 10−042.13 × 10−03− 1.46 × 10−041.72 × 10−02STG167−4.2 × 10−037.73 × 10−080.014.63 × 10−08− 6.08 × 10−049.01 × 10−02− 2.04 × 10−041.5 × 10−02PHG160− 4.96 × 10−035.05 × 10−090.011.26 × 10−10− 9.99 × 10− 041.85 × 10−03− 2.1 × 10−042.58 × 10−02IFG159−2.58 × 10−033.82 × 10−043.53 × 10−031.96 × 10−05− 7.41 × 10−041.51 × 10−02− 2.04 × 10−041.26 × 10−02The cell-type proportions from AD cases and control were inferred from bulk RNA-seq using the ssNMF method. Effects of AD and associations with additional clinical and pathological phenotypes in cell-type distributions were estimated using linear regression modelCB cerebellum, TC temporal cortex, APC anterior prefrontal cortex, SGT superior temporal gyrus, PHG parahippocampal gyrus, IFG inferior frontal gyrus