In Table 4, we present the results of our analysis of genes that simultaneously exceed various thresholds of α in the schizophrenia and bipolar datasets. The first two data rows labelled schizophrenia (SZ) and bipolar (BD) give the numbers of genes observed in the respective GWAS datasets at thresholds of α depicted at the top of each row (extracted from the previous two tables). The third row gives the number of genes common to both datasets at these thresholds. The bottom section of the table summarizes the null expectations based on the permutation tests. The distributions of the number of significant genes common to schizophrenia and bipolar disorder in the permuted data are not normal and therefore to characterise the distribution, we present the median, minimum, and maximum of the numbers of overlapping genes in the permuted data. We also present empirical p-values for observing the true dataset under the null. P-values are two-tailed since observing fewer genes across disorders than expected by chance would have a biological meaning as risk for one disorder could in principle reduce risk for the other.
