The results of the gene-wide analyses for schizophrenia and bipolar disorder are shown in tables 2 and 3. We provide the observed numbers of genes surpassing various thresholds of α in the observed data. The expectations under the Null hypothesis (based upon permutation) are described by the mean and the SD. For the product of p, the thresholds at which the data were truncated are given and the resultant product p-value significance threshold in the α column. In the final two columns, we present p-values (empirical and calculated) for the observed data under the 1-tailed null hypothesis of no excess of genes surpassing the thresholds. We use 1-tailed tests since the observation of fewer significant genes than chance has no biological meaning. In each disorder, there is a significant, or highly significant, excess in the observed number of genes surpassing virtually all thresholds regardless of the method for calculating gene-wide significance. The data from these tables are depicted graphically in Figure S1.
