In table 1, we present the numbers of SNPs in the observed data surpassing various nominal thresholds for α within and external to genes, the mean and the standard deviations of the same from the permuted data, and the empirical p values (2-tailed) for the null distribution in the observed dataset. For schizophrenia, there is a highly significant excess of SNPs within genes at the two more stringent thresholds whereas this was the case for bipolar disorder only at the intermediate threshold (P<0.01). For neither disorder did we observe a significant excess of associated SNPs located beyond the boundaries of genes. These results suggest that focussing on genes enriches for detectable association signals (in samples of the size we have utilized) providing support for a gene-centric approach.
