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Chunk #24 — Discussion

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EEG microstate analysis in drug-naive patients with panic disorder.
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In microstate class D, there was no significant difference between patients with PD and normal controls. In previous studies, patients with schizophrenia typically showed shortening of microstates of class D [35]–[36], [50]. A recent study demonstrated that one of the EEG microstate (identical with class D in the present study) was correlated with negative BOLD signal in right-lateralized dorsal and ventral areas of frontal and parietal cortex [18]. These areas correspond to RSN ‘2’ in the study by [20] and this RSN has been reported to be involved in attention [56]. In patients with schizophrenia, various cognitive dysfunctions including attentional deficits have been reported [57]. On the contrary, in patients with PD, cognitive functions are relatively intact [58], while selective aberrant processing for threatening stimuli has been reported in PD [59]. These preserved cognitive abilities in PD may correlate with the normal properties of microstate class D in the present study.