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Chunk #67 — Results — Single-trait QTL analysis in the expanded BXD RI lines

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High-throughput behavioral phenotyping in the expanded panel of BXD recombinant inbred strains.
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as input. Permutation thresholds for significant and suggestive LOD scores were 3.78 and 2.21, respectively, in males and 3.6 and 2.27, respectively, in females. Interval mapping of tail clip latency for males of the full BXD RI panel shows suggestive QTL on Chr 2 (LOD = 2.8) and 9 (LOD = 3.5), whereas suggestive QTL for females of the full panel are located on Chr 1 (LOD = 3.5), 11 (LOD = 3.0) and 17 (LOD = 2.5). Genes within the one-LOD confidence interval from QTL peaks for males (Chr 2: 77–97 Mb; Chr 9: 44–48 Mb) and females (Chr 1: 90–95 Mb and 97–107 Mb; Chr 11: 53–55 Mb; Chr 17: 78–84 Mb) were exported as positional candidate gene lists. These results, generated in the full RI panel (BXD 1–100) were compared with interval mapping results generated from previously available BXD RI lines including just the original set (Taylor I, BXD 1–32), and with exclusive use of the recent RI lines by Taylor (Taylor II, BXD 33–42) and by Peirce and colleagues (BXD 43–100). Quantitative trait locus mapping for each of the four sets (two male and two female sets) was performed. In females, suggestive QTL were detected on