RI lines by Taylor (Taylor II, BXD 33–42) and by Peirce and colleagues (BXD 43–100). Quantitative trait locus mapping for each of the four sets (two male and two female sets) was performed. In females, suggestive QTL were detected on Chr 1 and 9 for Taylor I (Fig. 2a), and Chr 8 for the recent RI set (Fig. 2b). Mapping of tail clip latency in males showed no suggestive QTL for Taylor I (Fig. 2d) and three suggestive QTL on Chr 2, 9 and 18 for the recent RI set (Fig. 2e). The marker present at the peak of the suggestive QTL for females is gnf01.018.340 (Chr 1 at 21.43 Mb). This single nucleotide polymorphism (SNP) lies within the Kcnq5 potassium channel gene (KCNQ5) (UCSC genome browser, http://genome.ucsc.edu/index.html, July 7, 2009). KCNQ channel (K(V)7.2-5) genes have been implicated in neuropathic pain (Gribkoff 2008). The effect at this marker across the Taylor I and recent BXD RI set indicates that while mice with the D allele have consistent phenotypic means across both sets, mice with the B allele have higher means in the Taylor I lines and lower means in the recent lines relative to the D2 allele. However, in the
